Programme

Day 1, Saturday, Sept 6th

• 16:00 Opening of the organizing secretariat and registration - Bilbao School of Engineering (SE).
• 17:00-17:30 Welcome address
  Luis Antonio Parada (CIC bioGUNE)
  Alberto Fernández (Basque Country Government)
• 17:30-18:30 Opening Lecture: The polygenic model of inherited cancer susceptibility comes of age. Richard Houlston (UK)Chair: Charles Buys
• 19:00-20:00 Welcome reception

Day 2, Sunday, Sept 7th

• • 09:00-13:00 Genetic changes in solid tumours.
  • 09:00-9:40 Chair: Paul Edwards
  • 09:00-09:40 Lecture: Genome-wide analysis of solid tumours.
    Tobias Sjöblom (Sweden)
  • 09:40-10:40 Oral presentations from abstracts.
  • 09:40 High resolution survey of homozygous deletions in cancer.
    Graham Bignell (UK)
  • 10:00 Genomic profiling of breast cancer.
    Max Chaffanet (France)
  • 10:20 Chromosome translocations in breast cancer.
    Karen Howarth (UK)
  • 10:40-11:10 Coffee break. Posters viewing.
  • 11:10-13:00 Genetic changes in solid tumours.
  • 11:10-11:50 Chair: Juan Cigudosa
  • 11:10-11:50 Lecture: Applications of CGH microarrays in cancer research.
    Gerrit Meijer (The Netherlands)
  • 11:50-12:50 Oral presentations from abstracts.
  • 11:50 Patterns of genomic instability associated with cell cycle and DNA repair in Ewing sarcomas: Gene expression and a-CGH profiling.
    Bibiana Ferreira (Spain)
  • 12:10 Are ER+PR+ and ER+PR- breast tumours genetically different? An array-CGH study.
    Alma Carracedo (Spain)
  • 12:30 Genomic aberrations associated with poor survival in Malignant Peripheral Nerve Sheath Tumours.
    Helge Brekke (Norway)
• 12:50-14:30 Lunch. Posters viewing.
• • 14:30-18:10 Mechanism underlining tumourigenic genetic changes.
  • 14:30-15:10 Chair: Felix Mitelman
  • 14:30-15:10 Lecture: Modelling and mining cancer genomes. Ronald DePinho (USA)
  • 15:10-16:10 Oral presentations from abstracts.
  • 15:10 Comparative cytogenetic analysis of mouse models for breast cancer pinpoints to the amplification of the novel oncogene Septin 9.
    Cristina Montagna (USA)
  • 15:30 Molecular characterization of double minutes/homogeneously staining regions in selected tumour cell lines.
    Clelia Tiziana Storlazzi (Italy)
  • 15:50 Chromosome instability in bladder cancer: Centrosome abnormalities and CCND1 gene amplification.
    Javier del Rey (Spain)
  • 16:10-16:30 Coffee break. Posters viewing.
  • 16:30-17:10 Chair: Charles Buys
  • 16:30-17:10 Lecture: RNA interference screening reveals new components of the DNA damage checkpoint machinery.Claus Storgaard (Denmark)
  • 17:10-18:10 Oral presentations from abstracts.
  • 17:10 Functional validation of genomic and transcriptome profiles identifies candidate oncogenes in colon cancer.
    Jordi Camps (USA)
  • 17:30 Multidisciplinary evaluation of the role of reciprocal chromosome translocations and gene fusion in the pathogenesis of solid tumours.
    Francesco Acquadro (Spain)
  • 17:50 The renal cell carcinoma-associated oncogenic fusion protein PRCCTFE3 induces P21WAF1/CIP1-mediated cell cycle arrest.
    Klaas Medendorp (The Netherlands)

Day 3, Monday, Sept 8th

• • 09:00-11:00 Cancer cell biology.
  • 09:00-09:40 Chair: Lidia Larizza.
  • 09:00-09:40 Lecture: Stem cell plasticity and tumours formation. Malcolm Alison (UK)
  • 09:40-10:40 Oral presentations from abstracts.
  • 09:40 Molecular cytogenetic characterization of tumour initiating cells.
    Patrizia Gasparini (Italy)
  • 10:00 Characterization of spontaneously transformed murine epithelial cells.
    Hesed Padilla-Nash (USA)
  • 10:20 Genomic alterations and expression profiling in uveal melanoma.
    Emine Kilic (Tha Netherlands)
  • 10:40-11:10 Coffee break. Posters viewing.
  • 11:10-13:10 Epigenetic changes in solid tumours
  • 11:30-12:10 Chair: Rosa Miró
  • 11:30-12:10 Lecture: The epigenome of cancer cells. Manel Esteller (Spain)
  • 12:10-13:10 Oral presentations from abstracts.
  • 12:10 The role of telomere length in telomerase based anticancer therapies.
    Ignacio Fernández García (Spain)
  • 12:30 Spatial genome organization in cancer.
    Karen Meaburn (USA)
  • 12:50 Genome reorganization during invasive cell growth.
    Luciano Vellon (Spain)
• • 13:30-14:30Lunch. Agilent Technologies Conference.
• • 15:00-16:00 Epigenetic changes in solid tumours.
  • 15:00-16:00 Oral presentations. Chair: Juan Cigudosa.
  • 15:00 The epigenetics of human synovial sarcoma: Towards novel therapeutic strategies.
    Diederik de Bruijn (The Netherlands)
  • 15:20 Unbiased differential methylation screening assay for applications in cancer epigenetic research.
    Vladimir Strelnikov (Russia)
  • 15:40 Late-breaking research.
  • 16:00-16:30 Coffee break. Posters viewing.
  • 16:30-18:30 Technological advances.
  • 16:30-17:10 Chair: Paul Edwards
  • 16:30-17:10 Lecture: Visualization of molecular interactions in situ.
    Ola Söderberg (Sweden)
  • 17:10-17:30Oral presentations from abstracts.
  • 17:10 HAPPY Mapping: a flexible method for examination of genomic rearrangements in cancer genomes.
    Jessica Pole (UK)
  • 17:30 Identification of transcriptional targets by chIP-Sequencing in t(X;1)-positive renal cell carcinomas.
    Linda Brugmans (The Netherlands)
  • 17:50 Identification of genes harbouring nonsense mutations.
    Gerben Duns (The Netherlands)
  • 18:10 Array CGH after FISH-MD reveals that typical marker chromosomes in ovarian cancer frequently show fusions between 11q13 and 19p13.3.
    Jürg Weimer (Germany)
  • 19:00-22.00 Informal dinner at a cider house.

Day 4, Tuesday, Sept 9th

• 09:00-12:00 Clinical impact of gene changes & Future directions.
• 09:00-09:40 Chair: Manfred Schwab
• 09:00-09:40 Lecture: MicroRNAs and Cancer. Carlo Croce (USA)
• 09:40-10:40 Oral presentations from abstracts.
• 09:40 Novel genomic lesions in patients with unexplained microsatellite instable colorectal tumours.
  Roland Kuiper (The Netherlands)
• 10:00 Homozygous deletions may be markers of nearby heterozygous mutations: the complex deletion at FRA16D in the HCT116 colon cancer cell line removes exons of WWOX.
  Paul Edwards (UK)
• 10:20 Late-breaking research: Is the DNA damage response a tumour suppressor barrier?
  Oskar Fernández-Capetillo (Spain)
• 10:50-11:10 Coffee break.
• 11:10-11:50 Closing Lecture: Identification of somatic rearrangements to base-pair resolution using paired-end massively parallel sequencing.
  Peter Campbell (UK)
• 11:50-12:00 Closing remarks.