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2010/02/05
Structure of the Tumor Suppressor ING4
The tumor suppressor ING4 regulates gene transcription by recruiting chromatin remodeling complexes to active promoters. A team of CIC bioGUNE researchers has investigated the structure of ING4 and found that it forms dimers in vitro and in vivo.
The analysis of the structure suggests a mechanism for enhanced targeting of the histone acetylase complex HBO1 to specific chromatin sites.