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Functional Genomics Unit

Genetic analysis is being used to understand the fundamental mechanisms that underlie hereditary diseases. This will allow development of therapeutic strategies and diagnostic systems, both for hereditary diseases and for prediction of individual sensitivity to particular drugs.

The Functional Genomics Unit carries out research studies in the regulation of gene expression: in different cell types and during development. We use sophisticated molecular biology and genetics techniques to study the genes that control normal biological processes, such as the activation of the innate immune response to microbial infections and the mechanisms controlling the development of higher organisms. We are investigating genetic variants within human populations associated with particular diseases. The contribution of nutritional and environmental factors to the development of pathological conditions is also being examined.

Laboratory 1

Principal Investigator:
Rosa Barrio Olano
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Development of multicellular organisms requires the strict control of cell division and differentiation. In higher eukaryotes, this control is exerted by highly conserved...

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Laboratory 2

Principal Investigator:
Ana María Aransay Bañares
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The genetic polymorphisms are variants of the genome that appear by mutation in some individuals. These are transmitted to the descendants and acquire a certain frequency in the...

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Laboratory 3

Principal Investigator:
David Gubb
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Models of the innate immune response and genetic diseases in the fly Drosophila. The fruit-fly, Drosophila melanogaster, represents a very powerful model to...

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Laboratory 4

Principal Investigator:
Ugo Mayor
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Ubiquitination of neuronal proteins is an essential regulatory mechanism of brain function, and its failure is associated to a number of neurodegenerative conditions, including...

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