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2010/02/23
DNA replication with a polymerase of Y-family can cause new mutations.
Researchers from CIC bioGUNE, the Spanish Center for Co-operative Research in Biosciences(laboratory of Lucy Malinina), and their colleagues from the Memorial Sloan-Kettering Cancer Center from New York and the University of New York (USA), have found that DNA replication with a polymerase of Y-family which temporary replaces normal polymerases (enzymes that conduct the replication of DNA) on damaged DNA sites to prevent genetic mutations linked to various types of cancer, can cause new mutations. The founding explains the reasons why the defects in DNA often appear not at the very point of damage, but in the vicinity of the lesion. The research has been published in the prestigious scientific journal Nature Structural and Molecular Biology.
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