Activity Detail
Seminar
Guanine quadruplexes: Biological relevance, targeting strategies and probes.
Anne Petitjean
The past three decades have revealed how much conformational control of nucleic acids impacts their biology. Many aspects of cell regulation are now known to be controlled by nucleic acids non-duplex folding patterns, such as guanine quadruplexes.
It is therefore tempting for synthetic chemists to investigate small molecules that address these particular architectures, in an effort to regulate undesired processes, as in diseased states such as cancer, infections and neurological disorders.
This presentation highlights a few families of guanine quadruplex binders, their promise and limitations, towards possible therapeutic agents and nucleic acids probes.